HPMC Factory for India
The demand for high-quality pharmaceutical products in India has been on the rise in recent years. As a result, the need for pharmaceutical excipients, such as hydroxypropyl methylcellulose (HPMC), has increased significantly. The
HPMC Factory is a leading manufacturer of this excipient in India.
At HPMC Factory, we understand the importance of producing high-quality and reliable products that meet the needs of our clients. Our HPMC products have been tested and assured to meet the highest industry standards, making them ideal for pharmaceutical applications.
With production units across the globe, including Bosnia and Herzegovina, Philippines, Singapore, Malta, and now India, we are committed to expanding our reach and providing excellent services to our clients. Our state-of-the-art facilities, cutting-edge technology, and quality assurance measures ensure that our products meet and exceed the requirements stipulated by regulatory authorities.
Our team of experts is highly qualified in areas ranging from research and development to manufacturing, quality control, and quality assurance. This means that not only do we produce quality products, but they are also backed by deep insights and knowledge of the industry. From bones to teeth, HPMC excipient plays an important role in drug formulations. Our formulations of HPMC are aimed at reducing that corrosive action on calcium-enable medicines.
We pride ourselves on our commitment to customer satisfaction. Our team is always available to answer any questions, provide advice, or offer technical assistance based on the application required. We also offer a range of other added-value services, such as the provision of samples and product analysis, to our customers.
In conclusion, the HPMC Factory is perfectly positioned to cater to the needs of the Indian pharmaceutical market. As a leading manufacturer of HPMC, we guarantee quality, reliability, and expertise. So, whether you’re in Bosnia and Herzegovina, Philippines, Singapore, Malta, or indeed India, you can trust the HPMC Factory to provide nothing but the best HPMC products for your pharmaceutical applications.
Faq
What is the dosage of Hydroxypropyl Methylcellulose (HPMC) in putty powder?
HPMC has three functions in putty powder: thickening, water retention, and facilitating construction. It does not participate in any reaction. The formation of bubbles in putty powder can be caused by two reasons: (1) Excessive water content. (2) Applying another layer on top before the bottom layer has dried, which can also lead to the formation of bubbles.
What is the recommended viscosity of Hydroxypropyl Methylcellulose (HPMC)?
MC stands for methyl cellulose, which is a cellulose ether made from purified cotton through alkali treatment using chloromethane as the etherification agent, followed by a series of reactions. The degree of substitution is generally 1.6-2.0, and different degrees of substitution result in different solubilities. It belongs to non-ionic cellulose ethers.
1. Methyl cellulose's water retention depends on the amount added, viscosity, particle size, and dissolution rate. Generally, a higher amount, smaller particle size, and higher viscosity result in better water retention. Among these cellulose ethers, methyl cellulose and hydroxypropyl methyl cellulose have higher water retention.
2. Methyl cellulose is soluble in cold water but has difficulty dissolving in hot water. Its aqueous solution is stable within the pH range of 3-12. It has good compatibility with starch, guar gum, and many surfactants. Gelation occurs when the temperature reaches the gelation temperature.
3. Temperature variation significantly affects the water retention of methyl cellulose. Generally, higher temperatures result in poorer water retention. If the temperature of the mortar exceeds 40°C, the water retention of methyl cellulose decreases significantly, which adversely affects the workability of the mortar.
4. Methyl cellulose has a noticeable impact on the workability and adhesion of mortar. "Adhesion" refers to the adhesion force between the worker's application tool and the wall substrate, i.e., the shear resistance of the mortar. A higher adhesion leads to higher shear resistance, requiring more force from the worker during application and resulting in poorer workability. Among cellulose ether products, methyl cellulose has a moderate level of adhesion.
HPMC stands for Hydroxypropyl Methyl Cellulose. It is a non-ionic cellulose ether derived from refined cotton through alkalization, using epichlorohydrin and chloromethane as etherification agents in a series of reactions. The degree of substitution is generally between 1.2 and 2.0. Its properties vary with the ratio of methoxy content to hydroxypropyl content.
(1) Hydroxypropyl Methyl Cellulose is soluble in cold water, but it can be difficult to dissolve in hot water. However, its gelation temperature in hot water is significantly higher than that of methyl cellulose. Its solubility in cold water is greatly improved compared to methyl cellulose.
(2) The viscosity of Hydroxypropyl Methyl Cellulose depends on its molecular weight, with higher molecular weight leading to higher viscosity. Temperature also affects its viscosity, with viscosity decreasing as temperature rises. However, its viscosity is less affected by temperature compared to methyl cellulose. Its solution is stable when stored at room temperature.
(3) Hydroxypropyl Methyl Cellulose exhibits stability in acids and alkalis, and its aqueous solution is highly stable within the pH range of 2 to 12. It is minimally affected by sodium hydroxide and lime water, although alkalis can accelerate its dissolution and slightly increase its viscosity. It demonstrates stability in general salts, but at higher salt concentrations, the viscosity of Hydroxypropyl Methyl Cellulose solution tends to increase.
(4) The water retention capacity of Hydroxypropyl Methyl Cellulose depends on factors such as the dosage and viscosity, and at the same dosage, its water retention rate is higher than that of methyl cellulose.
(5) Hydroxypropyl Methyl Cellulose can be mixed with water-soluble high molecular weight compounds to form homogeneous solutions with higher viscosity. Examples include polyvinyl alcohol, starch ethers, and plant gums.
(6) Hydroxypropyl Methyl Cellulose exhibits higher adhesion in mortar construction compared to methyl cellulose.
(7) Hydroxypropyl Methyl Cellulose has better resistance to enzymatic degradation compared to methyl cellulose, and its solution is less likely to undergo enzymatic degradation.
Why does hydroxypropyl methylcellulose (HPMC) have an odor?
1. Hot water dissolution method: HPMC does not dissolve in hot water, but it can disperse evenly in hot water initially and then rapidly dissolve upon cooling. There are two typical methods described as follows:
(1) Place the required amount of hot water in a container and heat it to approximately 70°C. Gradually add HPMC while stirring slowly. Initially, HPMC will float on the water's surface and gradually form a slurry, which cools down under stirring.
(2) Add 1/3 or 2/3 of the required amount of water to a container and heat it to 70°C. Disperse HPMC according to method (1) to prepare a hot water slurry. Then, add the remaining cold water to the hot water slurry and cool the mixture after stirring.
2. Powder mixing method: Mix HPMC powder with a large amount of other powdered substances using a blender. Afterward, add water for dissolution. In this case, HPMC can dissolve without clumping because each tiny corner of the powder contains only a small amount of HPMC, which dissolves immediately upon contact with water. This method is commonly used in putty powder and mortar production.
What are the main technical indicators of Hydroxypropyl Methylcellulose (HPMC)?
In the application of HPMC in putty powder, it plays three roles: thickening, water retention, and facilitating construction. Thickening: Cellulose can thicken the mixture, maintain uniform suspension, and prevent sagging. Water retention: It slows down the drying process of putty powder and assists in the reaction of lime and calcium in water. Construction: Cellulose acts as a lubricant, improving the workability of the putty powder. HPMC does not participate in any chemical reactions; it only serves as an auxiliary agent. When putty powder is mixed with water and applied to the wall, a chemical reaction occurs because new substances are formed. However, if the putty powder is scraped off the wall, ground into powder, and reused, it is not suitable because a new substance (calcium carbonate) has already formed. The main components of lime and calcium powder are Ca(OH)2, CaO, and a small amount of CaCO3. The reaction can be represented as: CaO + H2O = Ca(OH)2 — Ca(OH)2 + CO2 = CaCO3 ↓ + H2O. Under the action of water and carbon dioxide in the air, lime and calcium carbonate are formed. HPMC only assists in water retention and the better reaction of lime and calcium; it does not participate in any reactions itself.